A.D. Writers in 1991 The Simpsons Their character, Homer, finally decides to solve the question of how he lost his hair. He was then the most famous bald man in the world, fiction or otherwise. In one episode, in a series of flashes, a panicked Homer screams in fear every time Marge’s wife says she is pregnant with another child. Then, he pulled out the big locks of his brown locks.

He provided a fun backdrop for his favorite character, but he also hinted at the popular concept of why some people lose their hair in middle age. Scientists have long suspected that stress plays a major role — and especially in the complexities of work, marriage, and childbearing. Doctors have noticed this trend in their patients for a long time, but the scientific method has not been completely clear.

Scientists at Harvard University now think they may have broken the code.

Trichologists have been fascinated by the question of why some people lose their hair and others do not. The ancient Egyptians believed that the use of donkey’s hoofs and hippopotamus to stop the process of shaving. A thousand years later, Julius Caesar tried to hide his curly hair with a top.

A.D. According to Bill Gates, who announced the “Increased Market Incentives” in 2013, billions of dollars a year to diagnose hair loss and treatment – more than the amount spent on malaria and HIV / AIDS.

But despite all the research, the answers are still unclear. “This is a huge hyena game,” said Dr. Greg Williams, president of the British Hair Rehabilitation Association. Each of these studies gives us a riddle, and we gradually begin to build the whole picture.

The most common form of hair loss is androgenetic alopecia, which affects about one-third of men by the age of 35 and half by the age of 50. Or half the female pattern baldness for women over the age of 65. It has long been thought to be genetic, and In 2008, after decades of research, over 1,000 people were tested and found to be on the verge of becoming a ‘bald gene.’ When bald people move together, they reveal two genes that increase the risk of hair loss. It is estimated that about 14 percent of men carry both genes.

In the next stage, there is telogen influenza, the causes of which are not well understood. It occurs when many follicles in the scalp enter the hair growth cycle (also known as telogen), but the next stage of growth (known as anesthesia) does not begin. It usually occurs as a major health event, such as surgery or illness; Or major life events, such as loss of life, unemployment, or relationship breakdown.

According to a study of more than 1,600 patients in China, people who have been hospitalized at Kovid Hospital have experienced some hair loss. Lancet Medical journal, probably because of the shock of their bodies after being infected and recovering.

For those affected by the influenza influenza, hair usually falls out suddenly, and at an astonishing rate, sometimes 300 to 500 hairs a day. Patients describe the horror of waking up to see fleas on a pillow: Or wash their hair in the shower with their hands.

It was this hair loss that was the focus of the Harvard Animal Science study published in the magazine Nature last month. Researchers have removed the adrenal glands, which are responsible for the production of the stress hormone corticosteroid, which is supposed to weaken the GAS6 protein that stimulates hair growth. When their tumors were removed, the mice could not feel much anxiety.

Scientists observed their hair growth, and rats’ hair follicles were in the telegenia for only 20 days, less than three times that of unaltered mice. The follicles are also involved in hair growth three times. Scientists then inserted the mice into GAS6 protein, which stimulated further hair growth.

As with any study of animals, there is no guarantee that the findings are valid for humans. But experts say that the scientific process will be the same. Those who did not participate in the study were told by Professor Ruy, a dermatologist at Northwestern University in Chicago Nature “Exciting” results “set the stage for treatment for severe hair loss.”

Vicky Jolif, a postgraduate professor and consultant dermatologist at Queen Mary University in London, says the Harvard Rat study has identified a trend in the clinic over a decade. “Stress has always been an important factor in the care of people with hair loss,” he said. Telegraph. “We can be sure that stress is a key player. This concept is really important because it has a scientific belief in that concept.

She has seen patients who suddenly lose their hair after illness or surgery, or after giving birth. Emotional problems, such as grief, communication problems, and financial problems, also play a role. “Usually there is a small gap. The worst happens, and then you usually have a gap of about three months, after which you notice hair loss.

Harvard’s study may also have beneficial effects on stress-induced hair loss. The authors of the study have hinted that GAS6 protein, which is essential for stimulating hair growth in mice – as a treatment, perhaps as a medicine or a cream applied to the scalp. “Reversing the expression of GAS6 can increase the inhibition of hair follicle stem cells — and may promote growth,” said Ya-Cheh Hussein, a professor of stem cell and regenerative biology at Harvard University. Nature.

Williams, however, was cautious. “These most important studies are in mice or animals and do not necessarily translate into human care,” he said. It does in some cases and not in much.

Regardless of the science, doctors agree that it is important to avoid long-term stress that contributes to long-term health problems, including hair loss (heart disease, obesity, and various mental illnesses). In the midst of a global epidemic, of course, that could be easier said than done.

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