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Rats appear to eat a high-fat diet (right) and a regular diet (left).

Obesity has been linked to the development of many human diseases. It is very common in people who are obese, heart disease, diabetes and other diseases. However, it is not entirely clear how parts of the body are deteriorating and losing function due to chronic obesity. In a recent article, Nature, Tokyo Medical and Dental University (TMDU), a team of researchers used mouse model experiments to examine how high-fat diets or hereditary obesity affect hair and hair loss. The authors show that it triggers some inflammatory symptoms, leading to hair loss (HFS), inhibiting hair regeneration, and ultimately leading to hair loss. Found.

Normally, HFSS regenerates each hair follicle cycle. This is part of the process of growing our hair. As people get older, HFSs are less able to replenish themselves, resulting in smaller HFSs and, as a result, thinner hair. People who are overweight are more likely to develop androgenic alopecia, but little is known about how thinning hair accelerates, how, and its molecular mechanisms. The TMDU team identified several strategies designed to address these issues.

“High-fat diets weaken HFCC and cause hair loss, especially in older mice,” says study author Hironobu Moringa. The expression of the HFSC was followed by the activation of the HFSC in rats and mice fed on a regular diet and the fate of those HFCs. Obese mice fed HFD. HFCs have been shown to alter the fate of keratinocytes on the skin. Or keratinocytes that secrete fat when they move. These rats show rapid hair loss and small hair follicles with HCC depletion.

The fate of hair follicle stem cells (HFSC) revealed that HFCs are converted into epidermal keratinocytes or sebum-secreting cells. Triglyceride spots appear in red.

“HCCC shows signs of oxidative stress and epidermal differentiation even after 4 consecutive days of HFD.

Senior author Amy K. Nishimura said: “The NS gene expression shows that HFCs have found a sign of fire cytokines in HFSC in high-fat mice.” HFCC The fire extinguisher significantly destroys the Sonic hedgehog symbol, which plays a major role in the renovation of the HCC.

Researchers have found that activating the Sonic hedgehog marking method can save HFSC depletion. “This can prevent hair loss caused by a high-fat diet,” said Nishimura.

This study is interesting for some cell changes and for tissue disorders that occur after obesity due to high fat diet or genetics and may open the door to future prevention and treatment. New insights to lighten hair and understand obesity-related disease.


Baldness True – Changes in the cell division result in thinning hair


For more information –
Moringaaga Hironobu et al. Nature (2021). DOI: 10.1038 / s41586-021-03624-x

It is offered by the University of Tokyo Medical and Dental

Quote: Losing Fat Can Save Hair (September 21, 2021) September 21, 2021 Retrieved from https://medicalxpress.com/news/2021-09-fat-hair.html

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