Cambridge, Mass. – A scientific breakthrough may be a thing of the past. Harvard researchers say that after the discovery of a protein that stimulates hair growth, baldness is on the horizon.
The discovery could lead to a cream that stimulates an unrestricted key supply for follicly challenges: a real cure for baldness, not a temporary hypothesis. In experiments, mice surgically removed their adrenal glands and successfully tripled their hair. The small organs above each kidney are the stress hormone cortisol (cortisol). This stops the GAS6 protein on its pathways.
Anxiety reactions such as anxiety, anger, and depression have been linked to male pattern baldness. Researchers estimate that survivors of COVID-19 may suffer from hair loss as a result of the shock.
Related author Ya-Chichi Hussu, professor of stem cell and regenerative biology, stress hormones slow down growth in mice by regulating hair stem cells, according to SWNS.
The study appeared in the journal Nature, Identifies a process that supports hair loss for the first time and explains how to reverse it, allowing for potential baldness.
“Although the mechanisms by which these changes occur are largely unknown, researchers say that chronic, high-risk stress can have a significant impact on tissue hemostasis.” “The stress hormone corticosteroid, produced by the adrenal gland and cortisol rods in humans, regulates hair follicle stem cell (HFSC) quiescence and hair growth in mice.
Turning the clock back on the hair age
The authors of the hormone regulate sleep and activity in hair follicle stem cells (HFSCs) in mice. Without systemic corticosteroids, every hair follicle grows more and more throughout its life cycle.
“When corticosteroid levels are high, hair follicles stay in place for an extended period of time and cannot be renewed,” he said. “Conversely, when corticosteroid is depleted, hair follicle cells are activated and new hair growth occurs.
An analysis found that corticosteroid inhibits GAS6 production. In the absence of the hormone, hair follicles promote proliferation.
Reversing the expression of GAS6 can lead to the inhibition of hair follicle stem cells — and may promote growth. ” Therefore, it may be possible to increase the regeneration of hair follicles by modulating the corticosteroid-GAS6 barrier using HCS.
Throughout the course of a person’s life, hair rotates in three stages: growth (or “anagen”), decay (“catagen”), and rest (“telogen”). During anesthesia, a follicle constantly pushes the hair shaft. In catagen the growth stops and the lower part is reduced, but the hair stays in place. During television, he stays asleep.
Under severe stress, many hair follicles enter this stage prematurely and the hair falls out quickly, leading to baldness. This lifespan is much shorter than control in corticosteroid-free mice; Less than 20 days compared to two to three months.
‘Exciting discoveries’ on the long journey to healing baldness
Their follicles are involved in hair growth approximately three times. However, researchers have restored their normal hair cycle by feeding corticosteroids. Interestingly, when various mild stressors were applied to the controls for nine weeks, corticosteroids stopped and hair stopped growing. These stressors include tilting, isolation, congestion, wet beds, rapid lighting changes, and blocking. It re-injects GAS6 into the skin without any side effects.
“These exciting discoveries lay the groundwork for the treatment of hair loss due to chronic stress,” says Professor Rui Yi, a dentist at Northwestern University.
The study also showed that GAS6 increases the expression of genes involved in cell division in HFSCs.
“Therefore, the authors may have developed an unprecedented mechanism that directly stimulates the activation of HFCs by promoting cell division,” says Professor E. “In aging skin, many progenitors (cells) often carry out DNA mutations, including those that are harmful to skin cancers – without the formation of tumors.
“Critical GAS6 expression will be crucial to see if it can unleash the potential growth potential of these fast but mutable HSCs,” he concludes. “Modern life is bound to suffer. But maybe, one day, it will be possible to fight the negative effects of chronic stress on our hair – by adding some GAS6.
SWNS author Mark Waghor contributed to this report.