Hair loss is becoming more and more common. More than 50% of the population suffers from hair loss at some point in their lives and affects the body image, social relationships and emotional health of individuals. Don’t worry. Good news is coming. Recently, a research team led by GAO Jianqing and LI Fangyuan at the College of Pharmaceutical Sciences of Geojiang University developed CeNZ – a composite metal-enzyme (Ce-MN) that allows oxidative stress to relieve stress and regenerate perifollicular microenvironment simultaneously. Treatment for androgenetic alopecia (AGA). The research findings are published in ACS Nano.

The most common type of hair loss is AGA, a chronic and progressive disease. Although many clinical drugs have been used for AGA treatment, they have not yet produced satisfactory results. There are also reports of side effects.

Illustration of androgenetic alopecia (AGA) by serial nanoparticle (CNH) -benerative microenvironment (CNN).

The main cause of AGA is the loss of hair follicles (HFs) in the nest, which is generally due to vascular insufficiency or oxidative stress in the peritoneal microenvironment.

Inadequate blood circulation in the bucket region of Aga patients leads to inadequate supply of nutrients and other bioactive molecules to HFAs, thereby limiting the transition of HFAs from telogen to anaga.

Characteristics of the theological and physical characteristics of the C-MNS system

In addition to vascularization, oxidative stress disrupts natural antibodies and triggers cell apoptosis in HFs. In addition, overexpressed oxygen species (ROS) can trigger premature aging of the skin papilla cells and subsequent androgen signaling and activation may inhibit the conversion of HFAs to telogen-to-aggregation through mediation.

Efficacy of vivo AGA therapy in the C-MNS system

Ce-MNs are characterized by remarkable mechanical strength. They can penetrate the skin efficiently. This secure Ce-MNs adhesive can reshape the oxide microenvironment around the HFAs, thus providing a promising strategy for AG treatment.

Vivo evaluation in the C-MNS system to reconstruct the perifollicular microenvironment

Ce-MNs can deliver CeNZ directly to the dermis and epidermis to relieve excess ROS with cataracts and suppositories. In the meantime, the mechanical stimulation initiated by the MNS administration has the potential to rejuvenate the microvascular system in the skin, thereby boosting NFN levels. The Ce-MNs system can promote hair growth.

Professor Gao and his team

“This type of CeNZ is characterized by strong enzyme-like activity and can degrade a variety of ROS, including superoxide anions, hydroxyl radicals, and hydrogen peroxide, thus improving HF microwave conditions. In our experiments on cells and animals in general, the use of CeNZ can significantly promote HF activation with little damage to skin cells or HF cells, ”said Gao. let it be.

“Two-dimensional nanometerials and enzymes have very special benefits,” he said. We are committed to controlled integration and the application of nanosomes. In addition to this study, we have already shown excellent therapeutic effects on liver damage, diabetes mellitus, and so on. We hope to continue to make new discoveries in the field of nanoparticles.

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